Surgical resection remains a mainstay in the treatment of malignant solid tumors. However,
the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …

Surgical resection continues to be the mainstay treatment for solid cancers even though
chemotherapy and immunotherapy have significantly improved patient overall survival and …

Background Lymph node status is a prognostic marker and strongly influences therapeutic
decisions in colorectal cancer (CRC). Objectives The objective of the study is to investigate …

Prehabilitation aims to increase the endurance capacity of patients who are awaiting major
surgery. However, there are no studies investigating the implementation of this demanding …

Simple Summary Intersphincteric resection (ISR) is the ultimate anus-preserving surgical
technique for very low-lying rectal cancers. The oncological safety of ISR has been …

Although 2D cell cultures are commonly used to predict therapy response, it has become
clear that 3D cultures may better mimic the in vivo situation and offer the possibility of …

Abstract p53 mutation is common and highly related to radiotherapy resistance in rectal
cancer. APR-246, as a small molecule, can restore the tumor-suppressor function to mutant …

Simple Summary Limited volumetric change after pre-operative radiotherapy (RT) suggests
that sarcomas generally do not undergo cell death. Senolytic drugs represent a highly …

Background Cancer survival estimates provide insights into the effectiveness of early
detection and treatment. The stage of cancer at diagnosis is an important determinant of …

Simple Summary Radiotherapy is a standard of care therapy that kills cancer cells but has
limited efficacy in targeting the resistant cancer stem cells (CSCs). The use of …