Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

The evolutionary origin of metazoan cell types such as neurons and muscles is not known.
Using whole-body single-cell RNA sequencing in a sponge, an animal without nervous …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain
pluripotency. These properties require transcription factors that specify the gene expression …

Engineering clinically relevant cells in vitro holds promise for regenerative medicine, but
most protocols fail to faithfully recapitulate target cell properties. To address this, we …

Many organs throughout the body maintain epithelial homeostasis by employing a mucosal
barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells …

Understanding the role of factors that regulate intestinal epithelial homeostasis and
response to injury and regeneration is important. The current literature describes several …

The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as
associated organs. To generate a functional intestine, a series of highly orchestrated …