[HTML][HTML] Hallmarks of neurodegenerative diseases

DM Wilson, MR Cookson, L Van Den Bosch… - Cell, 2023 - cell.com
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Supramolecular adhesive hydrogels for tissue engineering applications

Y Zhao, S Song, X Ren, J Zhang, Q Lin… - Chemical …, 2022 - ACS Publications
Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the
loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and …

[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface

H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis,. Here, we restored this …

[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Exosomes‐loaded Electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via Immunoregulation and enhancement of myelinated …

L Fan, C Liu, X Chen, L Zheng, Y Zou, H Wen… - Advanced …, 2022 - Wiley Online Library
Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury
(SCI) repair because they match the electrical and mechanical properties of neural tissue …

Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury

Z Álvarez, AN Kolberg-Edelbrock, IR Sasselli… - Science, 2021 - science.org
The signaling of cells by scaffolds of synthetic molecules that mimic proteins is known to be
effective in the regeneration of tissues. Here, we describe peptide amphiphile …

Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

An injectable rapid‐adhesion and anti‐swelling adhesive hydrogel for hemostasis and wound sealing

S Bian, L Hao, X Qiu, J Wu, H Chang… - Advanced Functional …, 2022 - Wiley Online Library
Injectable hydrogel adhesives integrating both rapid adhesion to wet tissues and anti‐
swelling in humid environments are highly desired for fast hemostasis and wound sealing in …

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data

JH Badhiwala, JR Wilson, CD Witiw, JS Harrop… - The Lancet …, 2021 - thelancet.com
Background Although there is a strong biological rationale for early decompression of the
injured spinal cord, the influence of the timing of surgical decompression for acute spinal …

[HTML][HTML] Moving beyond the glial scar for spinal cord repair

EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …