Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …

T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for
enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

CD4+ T cells play key roles in a range of immune responses, either as direct effectors or
through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg) …

Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

The accumulation of acidic metabolic waste products within the tumor microenvironment
inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains …