Nucleic acid vaccines have shown promising potency and efficacy for cancer treatment with
robust and specific T-cell responses. Improving the immunogenicity of delivered antigens …

Adaptive immunity provides protection against infectious and malignant diseases. These
effects are mediated by lymphocytes that sense and respond with targeted precision to …

The fundamental principle of immune checkpoint blockade (ICB) is to protect tumor-
infiltrating T cells from being exhausted. Despite the remarkable success achieved by ICB …

Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer
immunotherapies. However, these cells are numerically scarce and functionally exhausted …

Communication between tumors and lymph nodes carries substantial significance for
antitumor immunotherapy. Remodeling the immune microenvironment of tumor-draining …

Tissue-resident memory T cells (TRM cells) have become an interesting subject of study for
antitumor immunity in melanoma and other solid tumors. In the initial phases of antitumor …

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from
thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows …

Exhaustion is a state of CD8 T cell differentiation that occurs in settings of chronic Ag such
as tumors, chronic viral infection, and autoimmunity. Cellular differentiation is driven by a …

Background The spatial distribution of tumor-infiltrating T cells and its dynamics during
chemoradiotherapy combined with PD-1 blockade is little known in esophageal squamous …