Although antipsychotics that act via monoaminergic neurotransmitter modulation have
considerable therapeutic effect, they cannot completely relieve clinical symptoms in patients …

Depressed mice have lower numbers of microglia in the dentate gyrus (DG). Reversal of this
decline by a single low dose of lipopolysaccharide (LPS) may have antidepressant effects …

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is
presumed to underlie its rapid antidepressant effects. Moreover, ketamine's therapeutic …

Stress disorders are psychiatric disorders arising following stressful or traumatic events.
They could deleteriously affect an individual's health because they often co-occur with …

Esketamine provides an immediate and noticeable antidepressant effect, although the
underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been …

Background Depression is one of the most common mental diseases and the leading cause
of disability worldwide. A dysfunctional gut microbiota-brain axis is one of the main …

We recently reported that reversing the chronic stress-induced decline of microglia in the
dentate gyrus (DG) of the hippocampus by intraperitoneal injection of a low dose of …

Inflammation and glutamate (GLU) are widely thought to participate in the pathogenesis of
depression, and current evidence suggests that the development of depression is …

Carbon monoxide (CO), a byproduct of heme catalyzed by heme oxygenase (HO), has been
reported to exert antioxidant and anti-inflammatory actions, and to produce significant …

Depression is a very common disabling mental disorder, which is typically characterized by
high rates of disability and mortality. Although research into the various mechanisms of …