Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …

This review analyses the mechanisms by which lung fluid balance is strictly controlled in the
air-blood barrier (ABB). Relatively large trans-endothelial and trans-epithelial Starling …

Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …

Background Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli
by the repetitive recruitment and derecruitment of alveolar units. This study aims to …

Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of
injury throughout the lung parenchyma that alters regional alveolar opening and collapse …

Rationale: There is continued debate regarding the equivalency of positive-pressure
ventilation (PPV) and negative-pressure ventilation (NPV). Resolving this question is …

Background: Mechanical ventilation (MV) can induce pulmonary fibrosis. This study aims to
investigate whether MV-induced pulmonary fibrosis is associated with aerobic glycolysis …

How acute respiratory distress syndrome progresses from underlying disease or trauma is
poorly understood, and there are no generally accepted treatments resulting in a 40 …

Background Ventilator-induced lung injury (VILI) is a complex pathophysiological process
leading to acute respiratory distress syndrome (ARDS) and poor outcomes in affected …

Objectives: Elucidate how the degree of ventilator-induced lung injury due to atelectrauma
that is produced in the injured lung during mechanical ventilation is determined by both the …