Pathophysiology of acute respiratory distress syndrome and COVID-19 lung injury
KE Swenson, ER Swenson - Critical care clinics, 2021 - criticalcare.theclinics.com
Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …
Pulmonary interstitial matrix and lung fluid balance from normal to the acutely injured lung
This review analyses the mechanisms by which lung fluid balance is strictly controlled in the
air-blood barrier (ABB). Relatively large trans-endothelial and trans-epithelial Starling …
air-blood barrier (ABB). Relatively large trans-endothelial and trans-epithelial Starling …
Computational lung modelling in respiratory medicine
Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …
Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway
P Ding, R Yang, C Li, HL Fu, GL Ren, P Wang… - Critical Care, 2023 - Springer
Background Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli
by the repetitive recruitment and derecruitment of alveolar units. This study aims to …
by the repetitive recruitment and derecruitment of alveolar units. This study aims to …
First stabilize and then gradually recruit: a paradigm shift in protective mechanical ventilation for acute lung injury
GF Nieman, DW Kaczka, PL Andrews, A Ghosh… - Journal of clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of
injury throughout the lung parenchyma that alters regional alveolar opening and collapse …
injury throughout the lung parenchyma that alters regional alveolar opening and collapse …
Positive-and negative-pressure ventilation characterized by local and global pulmonary mechanics
S Sattari, CA Mariano, WG Kuschner… - American Journal of …, 2023 - atsjournals.org
Rationale: There is continued debate regarding the equivalency of positive-pressure
ventilation (PPV) and negative-pressure ventilation (NPV). Resolving this question is …
ventilation (PPV) and negative-pressure ventilation (NPV). Resolving this question is …
[HTML][HTML] Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis
S Mei, Q Xu, Y Hu, R Tang, J Feng, Y Zhou, S Xing… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Mechanical ventilation (MV) can induce pulmonary fibrosis. This study aims to
investigate whether MV-induced pulmonary fibrosis is associated with aerobic glycolysis …
investigate whether MV-induced pulmonary fibrosis is associated with aerobic glycolysis …
Evolution of interfacial mechanics of lung surfactant mimics progression of acute respiratory distress syndrome
CO Ciutara, SV Iasella, B Huang… - Proceedings of the …, 2023 - National Acad Sciences
How acute respiratory distress syndrome progresses from underlying disease or trauma is
poorly understood, and there are no generally accepted treatments resulting in a 40 …
poorly understood, and there are no generally accepted treatments resulting in a 40 …
Necrostatin-1 attenuates Caspase-1-dependent pyroptosis induced by the RIPK1/ZBP1 pathway in ventilator-induced lung injury
RG Shao, QW Xie, LH Pan, F Lin, K Qin, SP Ming, JJ Li… - Cytokine, 2022 - Elsevier
Background Ventilator-induced lung injury (VILI) is a complex pathophysiological process
leading to acute respiratory distress syndrome (ARDS) and poor outcomes in affected …
leading to acute respiratory distress syndrome (ARDS) and poor outcomes in affected …
[HTML][HTML] Atelectrauma versus volutrauma: a tale of two time-constants
Objectives: Elucidate how the degree of ventilator-induced lung injury due to atelectrauma
that is produced in the injured lung during mechanical ventilation is determined by both the …
that is produced in the injured lung during mechanical ventilation is determined by both the …