Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Inflammation-induced inhibition of the insulin signalling pathway can lead to insulin
resistance and contribute to the development of type 2 diabetes mellitus (T2DM). Obesity …

Human type 1 diabetes (T1D) is an autoimmune disease associated with major
histocompatibility complex polymorphisms, β-cell autoantibodies, and autoreactive T cells …

The adaptive immune repertoire plays a critical role in type 1 diabetes (T1D) pathogenesis.
However, efforts to characterize B cell and T cell receptor (TCR) profiles in T1D subjects …

Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that
leads to type 1 diabetes, yet the key features of this immune-mediated process remain …

Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs
(miRNAs) are small noncoding RNAs that control gene expression and organ formation …

Inflammation is one of the main mechanisms of pancreatic β-cell damage and the
development of type 1 diabetes (T1D). Carvedilol, a beta-adrenergic receptor blocker, has …

T cell-mediated recognition of peptide-major histocompatibility complex (pMHC) class I and
II molecules is crucial for the control of intracellular pathogens and cancer, as well as for …

In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in
the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells …

IL-2 plays a critical role in the normal function of the immune system. A trophic factor for
lymphocytes, IL-2 is required for mounting and sustaining adaptive T cell responses; …