Biomaterials are extensively used to mimic cell–matrix interactions, which are essential for
cell growth, function, and differentiation. This is particularly relevant when developing in vitro …

Liver diseases are the primary reason for morbidity and mortality in the world. Owing to a
shortage of organ donors and postoperative immune rejection, patients routinely suffer from …

Drug-induced hepatotoxicity is a leading cause of clinical trial withdrawal. Therefore, in vitro
modeling the hepatic behavior and functionalities is not only crucial to better understand …

Three-dimensional printing technology has been used for more than three decades in many
industries, including the automotive and aerospace industries. So far, the use of this …

Three-dimensional (3D) bioprinting is an advanced tissue engineering technique that has
received a lot of interest in the past years. We aimed to highlight the characteristics of …

Bioprinting is a key technique to fabricate cell-laden volumetric constructs with controlled
geometry. It can be used not only to replicate the architecture of a target organ but also to …

Simple Summary This article provides a review of recent studies that explore the application
of the 3Rs in experimental animal models of liver disease, comparing different models for a …

Liver fibrosis occurs in many chronic liver diseases, while severe fibrosis can lead to liver
failure. A chitosan‐phenol based self‐healing hydrogel (CP) integrated with decellularized …

Hepatotoxicity‐related issues are poorly predicted during preclinical experimentation, as its
relevance is limited by the inadequacy to screen all the non‐physiological subclasses of the …

Over the past decade, the development of three-dimensional (3D) models has increased
exponentially, facilitating the unravelling of fundamental and essential cellular mechanisms …