Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by polymerization
of hemoglobin S upon deoxygenation that results in the formation of rigid sickled-shaped red …

Cell dehydration is a distinguishing characteristic of sickle cell disease and an important
contributor to disease pathophysiology. Due to the unique dependence of Hb S …

Hydroxyurea (hydroxycarbamide) is an effective treatment for sickle cell anaemia (SCA), but
clinical responses depend primarily upon the degree of fetal haemoglobin (HbF) induction …

Abstract Etavopivat (FT‐4202) is an orally administered, small‐molecule allosteric activator
of erythrocyte pyruvate kinase‐R (PKR) in clinical development for the treatment of sickle …

Sickle cell disease is an inherited blood disorder afflicting an estimated 100,000 individuals
in the United States and over 20 million people worldwide. The disease is heralded as the …

It is well documented that caffeic acid (3, 4‐dihydroxycinnamic acid)(CA) interacts with and
inhibits the oxidative reactions of myoglobin (Mb) and hemoglobin (Hb), and this interaction …

Polymerization of the sickle hemoglobin (HbS) is a key determinant of sickle cell disease
(SCD), an inherited blood disorder. Fetal hemoglobin (HbF) is a major modulator of the …

Sickle cell disease (SCD) is an exemplar of bidirectional translational research, starting with
a remarkable astute observation of the abnormally shaped red blood cells that motivated …

The pathology of sickle cell disease is caused by polymerization of the abnormal
hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to …

Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer
prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF …