Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and
exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent …

The microtubule-based cilium that extends from the surface of most eukaryotic cell types
serves motility, sensory reception and cell–cell signaling functions, and is disrupted in wide …

Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …

Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity.
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …

The melanin-concentrating hormone (MCH) system is involved in numerous functions,
including energy homeostasis, food intake, sleep, stress, mood, aggression, reward …

Primary cilia function as cells' antennas to detect and transduce external stimuli and play
crucial roles in cell signaling and communication. The vast majority of cilia genes that are …

Intracellular trafficking is mediated by transport carriers that originate by membrane
remodeling from donor organelles. Tubular carriers contribute to the flux of membrane lipids …

Almost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the
significance of cilia, once considered vestigial organelles, in the higher-order brain functions …

The Pallidin protein is a central subunit of a multimeric complex called biogenesis of
lysosome-related organelles complex 1 (BLOC1) that regulates specific endosomal …

In diabetes mellitus, death of β cell in the pancreas occurs throughout the development of
the disease, with loss of insulin production. The maintenance of β cell number is essential to …