Computational medicine: translating models to clinical care
RL Winslow, N Trayanova, D Geman… - Science translational …, 2012 - science.org
Because of the inherent complexity of coupled nonlinear biological systems, the
development of computational models is necessary for achieving a quantitative …
development of computational models is necessary for achieving a quantitative …
New tools for immunologists: models of lymph node function from cells to tissues
T Ozulumba, AN Montalbine… - Frontiers in …, 2023 - frontiersin.org
The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …
response to antigens and other foreign particles. Central to its function is the distinct spatial …
Modeling lymph flow and fluid exchange with blood vessels in lymph nodes
Abstract Background: Lymph nodes (LNs) are positioned strategically throughout the body
as critical mediators of lymph filtration and immune response. Lymph carries cytokines …
as critical mediators of lymph filtration and immune response. Lymph carries cytokines …
A time delay model of tumour–immune system interactions: Global dynamics, parameter estimation, sensitivity analysis
FA Rihan, DHA Rahman, S Lakshmanan… - Applied Mathematics …, 2014 - Elsevier
Recently, a large number of mathematical models that are described by delay differential
equations (DDEs) have appeared in the life sciences. In this paper, we present a delay …
equations (DDEs) have appeared in the life sciences. In this paper, we present a delay …
The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device
PM Rosa, N Gopalakrishnan, H Ibrahim, M Haug… - Lab on a Chip, 2016 - pubs.rsc.org
T cells play a central role in immunity towards cancer and infectious diseases. T cell
responses are initiated in the T cell zone of the lymph node (LN), where resident antigen …
responses are initiated in the T cell zone of the lymph node (LN), where resident antigen …
Persistence and adaptation in immunity: T cells balance the extent and thoroughness of search
Effective search strategies have evolved in many biological systems, including the immune
system. T cells are key effectors of the immune response, required for clearance of …
system. T cells are key effectors of the immune response, required for clearance of …
Quantitative measurement of naïve T cell association with dendritic cells, FRCs, and blood vessels in lymph nodes
T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search
lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is …
lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is …
The biophysics of lymphatic transport: engineering tools and immunological consequences
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph
node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here …
node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here …
Agent‐based modeling in systems pharmacology
Modeling and simulation (M&S) techniques provide a platform for knowledge integration and
hypothesis testing to gain insights into biological systems that would not be possible a priori …
hypothesis testing to gain insights into biological systems that would not be possible a priori …
Low levels of T cell exhaustion in tuberculous lung granulomas
The hallmarks of pulmonary Mycobacterium tuberculosis infection are lung granulomas.
These organized structures are composed of host immune cells whose purpose is to contain …
These organized structures are composed of host immune cells whose purpose is to contain …