A change of heart: Mechanisms of cardiac adaptation to acute and chronic hypoxia

AM Williams, BD Levine… - The Journal of …, 2022 - Wiley Online Library
Over the last 100 years, high‐altitude researchers have amassed a comprehensive
understanding of the global cardiac responses to acute, prolonged and lifelong hypoxia …

The effect of hypoxemia on muscle sympathetic nerve activity and cardiovascular function: a systematic review and meta-analysis

MM Tymko, D Young, D Vergel… - American Journal …, 2023 - journals.physiology.org
We conducted a systematic review and meta-analysis to determine the effect of acute
poikilocapnic, high-altitude, and acute isocapnia hypoxemia on muscle sympathetic nerve …

The role of (pro) renin receptor and its soluble form in cardiovascular diseases

B Wang, H Jie, S Wang, B Dong, Y Zou - Frontiers in Cardiovascular …, 2023 - frontiersin.org
The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular
diseases. In addition to the circulating RAS, local tissue RAS has been identified in various …

Knowledge, attitude, and practice of atrial fibrillation in high altitude areas

K Li, J Liu, Y Zhu - Frontiers in Public Health, 2024 - frontiersin.org
Background To investigate the knowledge, attitude, and practice (KAP) of atrial fibrillation
(AF) among the general population in high-altitude areas. Methodology A web-based cross …

Adrenergic control of the cardiovascular system in deer mice native to high altitude

OH Wearing, D Nelson, CM Ivy, DA Crossley II… - Current research in …, 2022 - Elsevier
Studies of animals native to high altitude can provide valuable insight into physiological
mechanisms and evolution of performance in challenging environments. We investigated …

Tibetans exhibit lower hemoglobin concentration and decreased heart response to hypoxia during poikilocapnia at intermediate altitude relative to Han Chinese

EA Moya, JJ Yu, S Brown, W Gu, ES Lawrence… - Frontiers in …, 2024 - frontiersin.org
Background High-altitude populations exhibit distinct cellular, respiratory, and
cardiovascular phenotypes, some of which provide adaptive advantages to hypoxic …

A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders

A Patrician, JD Anholm, PN Ainslie - The Journal of Physiology, 2024 - Wiley Online Library
Periodic breathing during sleep at high altitude is almost universal among sojourners. Here,
in the context of acclimatization and adaptation, we provide a contemporary review on …

Changes in cardiac function following a speed ascent to the top of Europe at 4808 m

B Champigneulle, S Doutreleau, S Baillieul… - European Journal of …, 2022 - Springer
Purpose Both prolonged exercise and acute high-altitude exposure are known to induce
cardiac changes. We sought to describe the cardiac responses to speed climbing at high …

Duration at high altitude influences the onset of arrhythmogenesis during apnea

LF Berthelsen, S Van Diepen, AR Steele… - European Journal of …, 2022 - Springer
Purpose Autonomic control of the heart is balanced by sympathetic and parasympathetic
inputs. Excitation of both sympathetic and parasympathetic systems occurs concurrently …

Acute moderate hypoxia reduces one-legged cycling performance despite compensatory increase in peak cardiac output: A pilot study

H Gatterer, V Menz, M Burtscher - International Journal of Environmental …, 2021 - mdpi.com
In severe hypoxia, single-leg peak oxygen uptake (VO2peak) is reduced mainly due to the
inability to increase cardiac output (CO). Whether moderate altitude allows CO to increase …