[HTML][HTML] Mitochondria in non-alcoholic fatty liver disease

ICM Simões, A Fontes, P Pinton, H Zischka… - The international journal …, 2018 - Elsevier
NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis
and to end-stage liver disease. The molecular mechanisms that cause the progression of …

A molecular insight into the role of antioxidants in nonalcoholic fatty liver diseases

D Ezhilarasan, T Lakshmi - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) defines fat accumulation in the liver, and it is
commonly associated with metabolic syndromes like diabetes and obesity. Progressive …

Moving to the rhythm with clock (circadian) genes, autophagy, mTOR, and SIRT1 in degenerative disease and cancer

K Maiese - Current neurovascular research, 2017 - ingentaconnect.com
Background: The mammalian circadian clock and its associated clock genes are
increasingly been recognized as critical components for a number of physiological and …

Exosomal RBP4 potentiated hepatic lipid accumulation and inflammation in high-fat-diet-fed mice by promoting M1 polarization of Kupffer cells

JM Yao, HZ Ying, HH Zhang, FS Qiu, JQ Wu… - Free Radical Biology and …, 2023 - Elsevier
Exosomes containing various biological cargoes have potential to be novel diagnostic
biomarkers for metabolic diseases. In this study, retinol-binding protein 4 (RBP4) was found …

Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies

ML Bonet, J Ribot, S Galmés, F Serra… - Biochimica et Biophysica …, 2020 - Elsevier
Antiobesity activities of carotenoids and carotenoid conversion products (CCPs) have been
demonstrated in pre-clinical studies, and mechanisms behind have begun to be unveiled …

[HTML][HTML] Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase …

MH Kim, JB Seong, JW Huh, YC Bae, HS Lee, DS Lee - Redox biology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver
disease globally. NAFLD—which can develop into liver fibrosis, nonalcoholic …

[HTML][HTML] Cognitive impairment and dementia: gaining insight through circadian clock gene pathways

K Maiese - Biomolecules, 2021 - mdpi.com
Neurodegenerative disorders affect fifteen percent of the world's population and pose a
significant financial burden to all nations. Cognitive impairment is the seventh leading cause …

[HTML][HTML] Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

K Maiese - Frontiers in bioscience (Landmark edition), 2021 - ncbi.nlm.nih.gov
Methods and results: Novel work with biological clock genes that oversee circadian rhythm
may meet this critical need by focusing upon the pathways of the mechanistic target of …

[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders

K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …

[HTML][HTML] The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …