Warburg effect, as an energy shift from mitochondrial oxidative phosphorylation to aerobic
glycolysis, is extensively found in various cancers. Interestingly, increasing researchers …

Pulmonary hypertension is a hemodynamic condition, defined as a mean pulmonary artery
pressure by right-sided heart catheterization of at least 25 mm Hg at rest. It is classified into 5 …

Importance Pulmonary hypertension (PH) is a fatal disease. Although the prognosis of
pulmonary arterial hypertension (PAH) has improved with targeted therapies, the outcome is …

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease of the lung
vasculature for which the molecular etiologies are unclear. Specific metabolic alterations …

Serotonin plays a key role in the development and maintenance of the pathobiology
associated with pulmonary arterial hypertension (PAH). Platelet‐driven and locally produced …

Background Pulmonary arterial hypertension (PAH) is a chronic disease of the pulmonary
vasculature that can lead to heart failure and premature death. Assessment of patients with …

The focus of this review is to increase awareness of pulmonary arterial hypertension (PAH)
in patients with rheumatic diseases. Epidemiology and pathogenesis of PAH in rheumatic …

Pulmonary arterial hypertension (PAH), which is a subset of pulmonary hypertension, is a
group of diseases distinguished by vascular remodeling of the small pulmonary arteries with …

Introduction Right heart failure (RHF) is a clinical syndrome with impaired right ventricular
cardiac output due to a variety of etiologies including ischemia, elevated pulmonary arterial …

Riociguat (Adempas®), an oral first-in-class soluble guanylate cyclase (sGC) stimulator, is
under global development by Bayer Healthcare Pharmaceuticals Inc. for the treatment of …