Purpose: Chordoma is a rare bone tumor with a high recurrence rate and limited treatment
options. The aim of this study was to identify molecular subtypes of chordoma that may …

Cancer predisposition syndromes (CPS) are known to cause a variety of sarcomas.
Consideration for genetic testing in patients with a strong family history of cancer, multiple …

Abstract Thiophanate-methyl (TM), a typical pesticide widely used worldwide, was detected
in rivers, soil, fruits, and vegetables. Thus, it is urgent to identify the potential harm of TM …

Chordoma is a rare malignant bone tumor that mainly occurs in the sacrum and the
clivus/skull base. Surgical resection is the treatment of choice for chordoma, but the local …

Chordoma is a rare malignant tumor demonstrating notochordal differentiation. It is
dependent on brachyury (TBXT), a hallmark notochordal gene and transcription factor, and …

Although multiple common susceptibility loci for lung cancer (LC) have been identified by
genome-wide association studies, they can explain only a small portion of heritability. The …

Little is known regarding the genomic alterations in chordoma, with the exception of loss of
SMARCB1, a core member of the SWI/SNF complex, in poorly differentiated chordomas. A …

Introduction Chordoma is a rare slow-growing tumor that occurs along the length of the
spinal axis and arises from primitive notochordal remnants (Stepanek et al., Am J Med Genet …

Résumé Le groupe des tumeurs notochordales s' est élargi dans la cinquième édition de la
classification de l'OMS des tumeurs osseuses et des tissus mous, et est constitué de la …