Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Current status of medical management for abdominal aortic aneurysm

J Golledge, PE Norman - Atherosclerosis, 2011 - Elsevier
Previous trials indicate that surgical management of small abdominal aortic aneurysms
(AAA) does not reduce mortality. The medical management of AAA, however, has to a large …

Fully automatic detection and segmentation of abdominal aortic thrombus in post-operative CTA images using deep convolutional neural networks

K López-Linares, N Aranjuelo, L Kabongo… - Medical image …, 2018 - Elsevier
Abstract Computerized Tomography Angiography (CTA) based follow-up of Abdominal
Aortic Aneurysms (AAA) treated with Endovascular Aneurysm Repair (EVAR) is essential to …

Association between metformin prescription and growth rates of abdominal aortic aneurysms

J Golledge, J Moxon, J Pinchbeck… - Journal of British …, 2017 - academic.oup.com
Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …

Geometric and biomechanical modeling aided by machine learning improves the prediction of growth and rupture of small abdominal aortic aneurysms

M Lindquist Liljeqvist, M Bogdanovic, A Siika… - Scientific reports, 2021 - nature.com
It remains difficult to predict when which patients with abdominal aortic aneurysm (AAA) will
require surgery. The aim was to study the accuracy of geometric and biomechanical analysis …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

Efficacy of telmisartan to slow growth of small abdominal aortic aneurysms: a randomized clinical trial

J Golledge, J Pinchbeck, SM Tomee… - JAMA …, 2020 - jamanetwork.com
Importance Currently there is no drug therapy for abdominal aortic aneurysm (AAA).
Objective To test the efficacy of the angiotensin receptor blocker telmisartan in slowing AAA …

[HTML][HTML] Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms

A Parr, M McCann, B Bradshaw, A Shahzad… - Journal of vascular …, 2011 - Elsevier
BACKGROUND:: Patients with abdominal aortic aneurysms (AAA) are predisposed to
cardiovascular events and often experience continual expansion of their aneurysm …

Combining volumetric and wall shear stress analysis from CT to assess risk of abdominal aortic aneurysm progression

O Meyrignac, L Bal, C Zadro, A Vavasseur, A Sewonu… - Radiology, 2020 - pubs.rsna.org
Background Despite known limitations, the decision to operate on abdominal aortic
aneurysm (AAA) is primarily on the basis of measurement of maximal aneurysm diameter …

Surrogate markers of abdominal aortic aneurysm progression

A Wanhainen, K Mani, J Golledge - … , thrombosis, and vascular …, 2016 - Am Heart Assoc
The natural course of many abdominal aortic aneurysms (AAA) is to gradually expand and
eventually rupture and monitoring the disease progression is essential to their management …