Therapeutic potential of Toll-like receptor 9 activation
AM Krieg - Nature reviews Drug discovery, 2006 - nature.com
In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
CpG motifs in bacterial DNA and their immune effects
AM Krieg - Annual review of immunology, 2002 - annualreviews.org
Unmethylated CpG motifs are prevalent in bacterial but not vertebrate genomic DNAs.
Oligodeoxynucleotides (ODN) containing CpG motifs activate host defense mechanisms …
Oligodeoxynucleotides (ODN) containing CpG motifs activate host defense mechanisms …
Immunotherapeutic uses of CpG oligodeoxynucleotides
DM Klinman - Nature Reviews Immunology, 2004 - nature.com
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
TOLL-like receptors linking innate and adaptive immune response
D Werling, TW Jungi - Veterinary immunology and immunopathology, 2003 - Elsevier
Invading pathogens are controlled by the innate and adaptive arms of the immune system.
Adaptive immunity, which is mediated by B and T lymphocytes, recognises pathogens by …
Adaptive immunity, which is mediated by B and T lymphocytes, recognises pathogens by …
Avian toll-like receptors
R Brownlie, B Allan - Cell and tissue research, 2011 - Springer
Abstract Analysis of the genomes of two distantly related bird species, chicken and zebra
finch (divergence of about 100 million years), indicate that there are ten avian toll-like …
finch (divergence of about 100 million years), indicate that there are ten avian toll-like …
Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides
R Brownlie, J Zhu, B Allan, GK Mutwiri, LA Babiuk… - Molecular …, 2009 - Elsevier
Similar to mammalian species, chickens show marked immunological responses to CpG
oligodeoxynucleotides (ODNs) both in vivo and in vitro. In mammals, the receptor for ODNs …
oligodeoxynucleotides (ODNs) both in vivo and in vitro. In mammals, the receptor for ODNs …
Use of CpG oligodeoxynucleotides as immune adjuvants
DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Identification and characterization of a functional, alternatively spliced Toll‐like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens
VJ Philbin, M Iqbal, Y Boyd, MJ Goodchild… - …, 2005 - Wiley Online Library
Based upon the recognition of antiviral compounds and single stranded viral RNA the Toll‐
like receptors TLR7 and TLR8 are suggested to play a significant role in initiating antiviral …
like receptors TLR7 and TLR8 are suggested to play a significant role in initiating antiviral …
Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres
M Diwan, M Tafaghodi, J Samuel - Journal of controlled release, 2002 - Elsevier
Synthetic oligodeoxynucleotides (ODN) consisting of unmethylated bacterial DNA
sequences with CpG motifs are potent immunological adjuvants. Immunostimulatory CpG …
sequences with CpG motifs are potent immunological adjuvants. Immunostimulatory CpG …
A road less travelled: large animal models in immunological research
WR Hein, PJ Griebel - Nature Reviews Immunology, 2003 - nature.com
The main advances in immunology have been forged or underpinned by animal
experiments. However, animal research now focuses excessively on one laboratory species …
experiments. However, animal research now focuses excessively on one laboratory species …