Cubosomes as oral drug delivery systems: a promising approach for enhancing the release of clopidogrel bisulphate in the intestine

HM El-Laithy, A Badawi, NS Abdelmalak… - Chemical and …, 2018 - jstage.jst.go.jp
Clopidogrel bisulphate (CB) is a first line antiplatelet drug for treatment of myocardial
infarction and stroke. Yet, its efficacy is limited by its poor solubility in intestinal pH, its main …

Continuous microchannel precipitation to enhance the solubility of telmisartan with poloxamer 407 using Box-Behnken design approach

P Shrimal, G Jadeja, J Naik, S Patel - Journal of Drug Delivery Science and …, 2019 - Elsevier
Poloxamer 407 encapsulated Telmisartan (TEL) nanoparticles were prepared by continuous
microchannel precipitation methodology to enhance Telmisartan's solubility and …

Evaluation of proanthocyanidin-crosslinked sericin/alginate blend for ketoprofen extended release

ED de Freitas, BM Lima, PCP Rosa… - Advanced Powder …, 2019 - Elsevier
Sericin and alginate blend has shown good results for obtaining sustained release dosage
forms. In the case of ketoprofen, it was necessary to resort to the use of the proanthocyanidin …

Preparation, characterization and biochemical studies of nanoformulations of chlorambucil to enhance anticancer efficacy

S Ahmed, M Nadeem, I Hussain, S Fatima… - New Journal of …, 2023 - pubs.rsc.org
Cancer, as a multifactorial disease, damages healthy cells and organs. The major drawback
of anticancer drugs is that they have a severe impact on healthy cells due to their toxic …

Encapsulation of Hibiscus sabdariffa Extract into Zein Nanoparticles

CM Calliari, R Campardelli, M Pettinato… - Chemical …, 2020 - Wiley Online Library
A combined approach for the extraction of antioxidants from Hibiscus sabdariffa and
entrapment of the extract in zein nanoparticles is proposed. Different green extraction …

Provesicular elastic carriers of Simvastatin for enhanced wound healing activity: An in-vitro/in-vivo study

SH Abd El-Alim, A Salama, AB Darwish - International Journal of …, 2020 - Elsevier
The aim of this study was to prepare and evaluate simvastatin (SIM) loaded elastic
provesicular systems for effective topical wound management. SIM provesicles were …

Norfloxacin loaded lipid polymer hybrid nanoparticles for oral administration: fabrication, characterization, in silico modelling and toxicity evaluation

MA Khan, S Khan, M Kazi, SM Alshehri, M Shahid… - Pharmaceutics, 2021 - mdpi.com
Norfloxacin (NOR), widely employed as an anti-bacterial drug, has poor oral bioavailability.
Nano based drug delivery systems are widely used to overcome the existing oral …

Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?

MM El-Sonbaty, MA Akl, M Khalid… - Journal of Drug Delivery …, 2022 - Elsevier
Luliconazole (LCZ) is a novel topical imidazole medication with broad-spectrum antifungal
activity. Unfortunately, the high potential of LCZ for topical antifungal activity is hampered by …

Fabrication and Assessment of Diosgenin Encapsulated Stearic Acid Solid Lipid Nanoparticles for Its Anticancer and Antidepressant Effects Using in vitro and in vivo …

H Khan, S Nazir, RK Farooq, IN Khan… - Frontiers in …, 2022 - frontiersin.org
Inflammatory cascade plays a pivotal role in the onset and progression of major depressive
disorder (MDD) and glioblastoma multiforme (GBM). Therefore, questing natural compounds …

Niosome-encapsulated doxycycline hyclate for potentiation of acne therapy: Formulation and characterization

F Kashani-Asadi-Jafari… - Pharmaceutical …, 2022 - ingentaconnect.com
Background: Acne is the pilosebaceous units' disorder. The most important cause of acne is
the colonization of bacteria in the follicles. Among antibiotics, doxycycline hyclate kills a …