Conspectus Drug-induced acute liver injury (DIALI) is increasingly recognized as a
significant cause of acute liver injury (ALI), which is characterized by a rapid loss of …

Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF)
in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the …

Acute-on-chronic liver failure (ACLF) is a distinct clinical entity and differs from acute liver
failure and decompensated cirrhosis in timing, presence of acute precipitant, course of …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Symptoms) is a complex multisystemic severe drug hypersensitivity reaction whose
diagnosis and management are troublesome. It involves the management by different …

Objective Antidepressant drugs can cause drug-induced liver injury (DILI). The authors
review clinical data relevant to antidepressant-induced liver injury and provide …

Non-steroidal anti-inflammatory drugs (NSAIDs) constitute a family of drugs, which taken as
a group, represents one of the most frequently prescribed around the world. Thus, not …

Idiosyncratic drug-induced liver injury (DILI) is an important cause of morbidity and mortality
following drugs taken in therapeutic doses. Hepatotoxicity is a leading cause of attrition in …

Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe
and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual …