The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that dimerizes
with ARNT to mediate responses to compounds such as 2, 3, 7, 8-tetrachlorodibenzo-p …

Previous research has shown that killifish (Fundulus heteroclitus) inhabiting a creosote-
contaminated site on the Elizabeth River in Virginia exhibit little induction of cytochrome …

Physiological development requires precise spatiotemporal regulation of cellular and
molecular processes. Disruption of these key events can generate developmental toxicity in …

In the embryo-larval stages of fish, alkylphenanthrenes such as retene (7-isopropyl-1-
methylphenanthrene) produce a suite of developmental abnormalities typical of exposure to …

Halogenated agonists for the aryl hydrocarbon receptor (AHR), such as 3, 3′, 4, 4′, 5-
pentachlorobiphenyl (PCB126) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), cause …

Abstract Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on local circulation and
apoptosis in the midbrain were investigated in zebrafish (Danio rerio) embryos during early …

Oxidative stress is an important mechanism of chemical toxicity, contributing to
developmental toxicity and teratogenesis as well as to cardiovascular and …

Japanese medaka (Oryzias latipes), a small freshwater fish used extensively to investigate
sexual differentiation and development, were exposed to octylphenol (OP), a known …

Studies in our laboratory have demonstrated that subchronic 2, 3, 7, 8,-tetrachlorodibenzo-p-
dioxin (TCDD) exposure of adult mice results in hypertension, cardiac hypertrophy, and …

Abstract The effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on regional
red blood cell (RBC) perfusion rate, as an index of blood flow, and lower jaw development …