Involvement of COX2–thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish

H Teraoka, Y Okuno, D Nijoukubo, A Yamakoshi… - Aquatic toxicology, 2014 - Elsevier
The cardiovascular system is one of the most characteristic and important targets for
developmental toxicity by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae …

Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo

YY Chen, KM Chan - Chemosphere, 2018 - Elsevier
Trace metal ions such as cadmium (Cd 2+) and trace organics typified by 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and …

Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment

F Hu, W Li, H Wang, H Peng, J He, J Ding… - Fish Physiology and …, 2023 - Springer
Abstract Tris (2-chloroethyl) phosphate (TCEP), a typical organophosphate flame retardant,
is of increasingly great concern considering their ubiquitous presence in aquatic …

[HTML][HTML] RNA-Sequencing Analysis of TCDD-Induced Responses in Zebrafish Liver Reveals High Relatedness to In Vivo Mammalian Models and Conserved …

ZH Li, H Xu, W Zheng, SH Lam, Z Gong - PLoS One, 2013 - journals.plos.org
TCDD is one of the most persistent environmental toxicants in biological systems and its
effect through aryl hydrocarbon receptor (AhR) has been well characterized. However, the …

Review of ecologically relevant in vitro bioassays to supplement current in vivo tests for whole effluent toxicity testing-Part 2: Non-apical endpoints

KA Finlayson, JP Van de Merwe, FDL Leusch - Science of The Total …, 2022 - Elsevier
Whole effluent toxicity (WET) testing uses whole animal exposures to assess the toxicity of
complex mixtures, like wastewater. These assessments typically include four apical …

Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD

K Hilscherova, AL Blankenship, M Nie… - … and Physiology Part C …, 2003 - Elsevier
2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was injected into chicken eggs prior to
incubation to study possible mechanisms of toxicity and teratogenicity. One of the suggested …

The toxicity of persistent organic pollutants to aquatic organisms

SM Harmon - Comprehensive Analytical Chemistry, 2015 - Elsevier
Persistent organic pollutants are of great concern because they tend to disperse widely
across ecosystems; they accumulate to high concentrations in the tissues of wildlife; and …

Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus)

DR Brown, J Thompson, M Chernick… - Environmental …, 2017 - Wiley Online Library
High‐level, acute exposures to individual polycyclic aromatic hydrocarbons (PAHs) and
complex PAH mixtures result in cardiac abnormalities in developing fish embryos. Whereas …

[HTML][HTML] Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity

A Alexeyenko, DM Wassenberg, EK Lobenhofer, J Yen… - PloS one, 2010 - journals.plos.org
Background In order to generate hypotheses regarding the mechanisms by which 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (dioxin) causes toxicity, we analyzed global gene expression …

Modification and quantification of in vivo EROD live-imaging with zebrafish (Danio rerio) embryos to detect both induction and inhibition of CYP1A

B Kais, R Ottermanns, F Scheller… - Science of the Total …, 2018 - Elsevier
The visualization of specific activation of the aryl hydrocarbon receptor (AhR) directly in the
zebrafish embryo (Danio rerio) via live-imaging is a reliable tool to investigate the presence …