The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as
their precursor cholesterol are required for successful establishment and maintenance of …

Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is
vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis …

The cholesterol-lowering blockbuster drug pravastatin can be produced by stereoselective
hydroxylation of the natural product compactin. We report here the metabolic reprogramming …

The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum
(ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol …

Cytochrome P450 enzymes are highly diversified biocatalysts associated with steroid
biosynthesis, xenobiotic metabolism, biosynthesis of natural products, and industrial …

Prenyltransferases (PTases) are known to play a role in embryonic development, normal
tissue homeostasis and cancer by posttranslationally modifying proteins involved in these …

Simvastatin is a semisynthetic cholesterol-lowering medication and one of the top-selling
statins in the world. Currently, industrial production of simvastatin acid (SVA) is a multistep …

Background: Data from recent meta-analyses question an association between dietary
intake of saturated fatty acids (SFAs) and risk of cardiovascular disease (CVD). Moreover …

Different pharmacological interventions have been applied with success to reduce the
progression of atherosclerosis. However, many patients are not good responders or must …

Several lines of evidence have shown that SORT1 gene within 1p13. 3 locus is an important
modulator of the low-density lipoprotein-cholesterol (LDL-C) level and atherosclerosis risk …