Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors

EJ Kwon, HJ Cha, H Lee - Iscience, 2024 - cell.com
Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical
outcomes in the treatment of various cancers. However, their widespread application has …

Sex steroid metabolism and actions in non-small cell lung carcinoma

T Asavasupreechar, MSM Chan, R Saito, Y Miki… - The Journal of Steroid …, 2019 - Elsevier
Despite recent development in targeted therapies, lung cancer still remains the leading
cause of cancer death. Therefore, a better understanding of its pathogenesis and …

Complex differential diagnosis between primary breast cancer and breast metastasis from EGFR-mutated lung adenocarcinoma: case report and literature review

C Valenza, FM Porta, A Rappa, E Guerini-Rocco… - Current …, 2021 - mdpi.com
We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung
adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The …

[HTML][HTML] Role of GPER1 in the Mechanism of EGFR-TKIs Resistance in Lung Adenocarcinoma

Z Li, Y Pan, Q Liu, J Wang, C Liu, L Qu, D Li - Frontiers in Oncology, 2022 - frontiersin.org
Epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors (TKIs) have a good
clinical efficacy in lung adenocarcinoma harboring activating-mutation EGFR. Such EGFR …

Autocrine 17-β-Estradiol/Estrogen Receptor-α Loop Determines the Response to Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer

DP Anobile, IC Salaroglio, F Tabbò, S La Vecchia… - Clinical Cancer …, 2023 - AACR
Purpose: The response to immune checkpoint inhibitors (ICI) often differs between genders
in non–small cell lung cancer (NSCLC), but metanalyses results are controversial, and no …

[PDF][PDF] Dual Effect of Immune Cells within Tumour Microenvironment: Pro-and Anti-Tumour Effects and Their Triggers. Cancers 2022, 14, 1681

AC Peña-Romero, E Orenes-Piñero - 2022 - mdpi.com
Our body is constantly exposed to pathogens or external threats, but with the immune
response that our body can develop, we can fight off and defeat possible attacks or …

The estrogen pathway as a modulator of response to immunotherapy

MA Velez, TF Burns, LP Stabile - Immunotherapy, 2019 - Future Medicine
Lung cancer is the leading cause of cancer deaths worldwide, with a 5-year survival rate of
about 18%. Thus, there is a great need for novel therapeutic approaches to treat non-small …

EGFR 靶向治疗的现状机遇和挑战

高琳, 虞永峰, 陆舜 - 中国肿瘤临床, 2021 - cjco.cn
肺癌是癌症相关死亡的主要原因. 目前, 肺癌的发病率正在下降, 但患者的生存率仍然较低.
肺癌中超过85% 是非小细胞肺癌(non-small cell lung cancer, NSCLC), 超过60% 的NSCLC …

Epidemiology and clinicopathological features of lung cancer in patients with prior history of breast cancer

KY Wang, J Newman, CS Lee… - SAGE Open …, 2021 - journals.sagepub.com
Breast cancer is the most common malignancy in women, and lung cancer, the leading
cause of cancer-related mortality in the United States, is the most common subsequent …

Development of a prognostic model for lung adenocarcinoma polarity‐related genes and analysis of immune landscape

H Xu, W Du, X Jing, J Xie, P Li - Biotechnology and Applied …, 2024 - Wiley Online Library
Despite the progress made in the management of lung adenocarcinoma (LUAD), the overall
prognosis for LUAD individuals remains suboptimal. While the role of cell polarity in tumor …