[HTML][HTML] Investigation of combination treatment with an aromatase inhibitor exemestane and carboplatin-based therapy for postmenopausal women with advanced …

PA Young, DC Márquez-Garbán, ZS Noor… - JTO clinical and …, 2021 - Elsevier
Abstract Introduction Estrogen receptors (ER)(ERα, ERβ) and aromatase (key enzyme for
estrogen synthesis) are expressed in most human NSCLCs. High intratumoral estrogen …

Estrogen Receptor [beta] in Cancer: To [beta](e) or not to [beta](e)?

NM Hwang, LP Stabile - Endocrinology, 2021 - go.gale.com
Estrogen receptors (ERs) are known to play an important role in the proper development of
estrogen-sensitive organs, as well as in the development and progression of various types …

The relationship between short-term surrogate endpoint indicators and mPFS and mOS in clinical trials of malignant tumors: A Case study of approved molecular …

M Rui, Z Wang, Z Fei, Y Wu, Y Wang, L Sun… - Frontiers in …, 2022 - frontiersin.org
Objective: Due to the initiation of the priority review program in China, many antitumor drugs
have been approved for marketing based on phase II clinical trials and short-term surrogate …

[HTML][HTML] Erlotinib enhanced chemoradiotherapy sensitivity via inhibiting DNA damage repair in nasopharyngeal carcinoma CNE2 cells

Y Zhang, F Zhou, J Zhang, Q Zou… - Annals of Palliative …, 2020 - apm.amegroups.org
Background: Nasopharyngeal carcinoma (NPC), arising from nasopharynx epithelium, is a
rare type of malignant carcinoma that has a specific geographical distribution and a high risk …

[HTML][HTML] Effect of erlotinib combined with cisplatin on IL‑6 and IL‑12 in mice with Lewis lung cancer

X Zhang, J Chen, H Jin, W Zhao… - Oncology …, 2020 - spandidos-publications.com
Abstract Effect of erlotinib combined with cisplatin on tumor growth, interleukin‑6 (IL‑6) and
interleukin‑12 (IL‑12) in mice with Lewis lung cancer (LLC) was investigated. Forty‑four pure …

[HTML][HTML] Estrogen Receptor β1 Expression Patterns Have Different Effects on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors' Treatment Response in …

L Zhang, M Tian, J Lin, J Zhang, H Wang, Z Li - Frontiers in Oncology, 2021 - frontiersin.org
Estrogen receptor β (ER β) can regulate cellular signaling through non-genomic
mechanisms, potentially promoting resistance to epidermal growth factor receptor (EGFR) …

Targeting Toll-like receptor 4 with CLI-095 (TAK-242) enhances the antimetastatic effect of the estrogen receptor antagonist fulvestrant on non-small cell lung cancer

S Fan, Y Liao, W Qiu, L Li, D Li, X Cao, B Ai - Clinical and Translational …, 2020 - Springer
Purpose Estrogen plays a critical role in the invasiveness and metastasis of non-small cell
lung cancer (NSCLC) through estrogen receptor β (ERβ). However, the antimetastatic effect …

[HTML][HTML] GPER1 在EGFR 突变的肺腺癌中的表达

王建, 李振华, 汪颖, 刘畅, 李定彪 - 中国肿瘤临床, 2021 - cjco.cn
GPER1在EGFR突变的肺腺癌中的表达 首页 期刊简介 1.期刊介绍 2.获奖情况 编委会 期刊在线
1.最新录用 2.优先发表 3.当期目录 4.过刊浏览 视频合辑 在线投稿 1.投稿须知 2.稿约下载 3.版权 …

案例報告: 原發性EGFR T790M 和L858R 突變之肺腺癌患者使用Afatinib 和抗雌激素療法

劉錦鳳, 楊璦瑜 - 臺灣臨床藥學雜誌, 2019 - airitilibrary.com
過去關於T790M 突變研究, 主要圍繞在tyrosine kinase inhibitors (TKIs) 治療後產生抗藥性;
原發性T790M 突變伴隨其他敏感性突變的研究有限, 且未有明確顯著的療效藥物. 本案例為1 …

[HTML][HTML] Aromatase inhibitors combined with aspirin to prevent lung cancer in preclinical models

PA Young, RJ Pietras - Translational lung cancer research, 2018 - ncbi.nlm.nih.gov
Results In their report published in the Journal of Thoracic Oncology from March 2018,
Stabile et al.(18) evaluated the combination of AIs and non-steroidal anti-inflammatory drugs …