[HTML][HTML] Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Q Xu, B Zhao, Y Ye, Y Li… - Journal of …, 2021 - jneuroinflammation.biomedcentral …
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

[HTML][HTML] Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment

X Guo, X Yin, Z Liu, J Wang - International Journal of Molecular Sciences, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease,
affecting approximately one-quarter of the global population, and has become a world public …

The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney …

X Li, Y Bai, W Zhu, X Shi, S Xu - Fish & shellfish immunology, 2022 - Elsevier
Imidacloprid (IMI), a systemic neonicotinoid insecticide widely used in agriculture, resulting
in persistence in aquatic environments that threaten the survival of organisms. Eucalyptol …

Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure

X Liu, Y Chen, H Wang, Y Wei, Y Yuan, Q Zhou… - Journal of Hazardous …, 2021 - Elsevier
Arsenic is the leading toxicant of hazardous environmental chemicals, which is linked with
neurotoxicity including cognitive dysfunction, neurodevelopmental alterations and …

[HTML][HTML] The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

S Makaremi, A Asgarzadeh, H Kianfar… - Inflammation …, 2022 - Springer
A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …

[HTML][HTML] Idebenone: When an antioxidant is not an antioxidant

N Gueven, P Ravishankar, R Eri, E Rybalka - Redox biology, 2021 - Elsevier
Idebenone is a well described drug that was initially developed against dementia. The
current literature widely portrays this molecule as a potent antioxidant and CoQ 10 …

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

X Wang, V Antony, Y Wang, G Wu… - Medicinal Research …, 2020 - Wiley Online Library
The innate immune system contains multiple classes of pattern recognition receptors
(PRRs), which recognize pathogen‐associated molecular patterns (PAMPs) and danger …

Endoplasmic Reticulum Stress Contributes to Copper-Induced Pyroptosis via Regulating the IRE1α-XBP1 Pathway in Pig Jejunal Epithelial Cells

J Liao, Z Hu, Q Li, H Li, W Chen, H Huo… - Journal of Agricultural …, 2022 - ACS Publications
Copper (Cu) is a common additive in food products, which poses a potential concern to
animal and human health when it is in excess. Here, we investigated the relationship …

Mitochondrial mutations and genetic factors determining NAFLD risk

SA Dabravolski, EE Bezsonov, MS Baig… - International Journal of …, 2021 - mdpi.com
NAFLD (non-alcoholic fatty liver disease) is a widespread liver disease that is often linked
with other life-threatening ailments (metabolic syndrome, insulin resistance, diabetes …

The NLRP3 inflammasome contributes to inflammation‐induced morphological and metabolic alterations in skeletal muscle

M Eggelbusch, A Shi, BC Broeksma… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Systemic inflammation is associated with skeletal muscle atrophy and
metabolic dysfunction. Although the nucleotide‐binding oligomerization domain‐like …