Parkinson's disease (PD) is the fastest-growing neurodegeneration disease, characterized
typically by a progressive loss of dopaminergic neurons in the substantia nigra, and there …

Background Endoplasmic reticulum (ER) stress plays an important role in the occurrence
and development of various liver diseases. However, there are no effective prevention and …

Metformin (Met) is a first-line and essential treatment for type 2 diabetes, with anti-
inflammatory effects. It has been reported Met could inhibit NF-κB activity and down-regulate …

Polycystic ovary syndrome (PCOS) is one of the most common gynecological endocrine
disorders, with sporadic ovulation, excessive androgens, and polycystic ovarian changes as …

Glycinin (11S) and β-conglycinin (7S) from soybean (glycine max) cause diarrhea and
intestinal barrier damage in young animals. Understanding the mechanisms underlying the …

Objective We investigated the proinflammatory functions of endoplasmic reticulum stress
and peroxisome proliferator-activated receptor α (PPARα) in the development of gestational …

The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum can cause
an endoplasmic reticulum stress (ERS) response. If ERS continues or cannot be alleviated, it …

The endoplasmic reticulum (ER), an essential organelle in eukaryotic cells, is widely
distributed in myocardial cells. The ER is where secreted protein synthesis, folding, post …

Bupivacaine is a common local anesthetic that causes neurotoxicity when used at clinical
concentrations. Melatonin (MT), is a potent neuroprotective molecule. The study aimed to …

Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the context of
chronic disease. Both are activated upon perceived disturbances in homeostasis, being …