Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is
characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss …

Aims Diabetic nephropathy (DN) is the foremost basis of end-stage kidney failure implicating
endoplasmic reticulum (ER) stress and dysregulation of Rho kinase/Rock pathway …

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease without early
diagnostic and specific therapeutic approaches. Podocyte apoptosis and loss play important …

Deposition of immune complexes in the glomerulus leads to irreversible renal damage in
lupus nephritis (LN), of which podocyte malfunction arises earlier. Fasudil, the only Rho …

Abstract The small GTPase Rho and its effector Rho-kinase (ROCK) are activated in the
diabetic kidney, and recent studies decade have demonstrated that ROCK signaling is an …

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus. This study
examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on DN and …

Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide.
Although remarkable therapeutic advances have been made during the last few years, there …

Salvia miltiorrhiza Bunge (Danshen) has been widely used to treat cancer and
cardiovascular diseases in Chinese traditional medicine. Here, we found that …

Focal segmental glomerulosclerosis (FSGS) shares podocyte damage as an essential
pathological finding. Several mechanisms underlying podocyte injury have been proposed …

Anti-partial epithelial-mesenchymal transition (pEMT) treatment of renal tubular epithelial
cells (TECs) represents a promising therapeutic approach. Hyperuricemia nephropathy (HN) …