The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias

MJ Curtis, JC Hancox, A Farkas, CL Wainwright… - Pharmacology & …, 2013 - Elsevier
The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Characterisation, utilisation and clinical relevance of isolated perfused heart models of ischaemia-induced ventricular fibrillation

MJ Curtis - Cardiovascular Research, 1998 - academic.oup.com
The isolated perfused heart has been used increasingly during the last decade as a model
for identifying actions of drugs on ventricular fibrillation (VF) induced by myocardial …

Limb ischemia preconditions the heart against reperfusion tachyarrhythmia

T Oxman, M Arad, R Klein, N Avazov… - American Journal of …, 1997 - journals.physiology.org
We investigated the hypothesis that a cardioprotective, antiarrhythmic effect might be
obtained by brief ischemia of a remote part of the body before ischemia of the heart …

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

MM Mocanu, GF Baxter… - British journal of …, 2000 - Wiley Online Library
Ischaemia‐reperfusion injury causes cell death by both necrosis and apoptosis. Caspase
activation is a major event in apoptosis. We therefore examined the effect of caspase …

Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol

LI Somova, FO Shode, M Mipando - Phytomedicine, 2004 - Elsevier
The cardiotonic and antidysrhythmic effects of four triterpenoid derivatives, namely oleanolic
acid (OA), ursolic acid (UA), and uvaol (UV), isolated from the leaves of African wild olive …

The protective effect of resveratrols on ischaemia‐reperfusion injuries of rat hearts is correlated with antioxidant efficacy

LM Hung, MJ Su, WK Chu, CW Chiao… - British journal of …, 2002 - Wiley Online Library
Dietary antioxidants are thought to be beneficial in reducing the incidence of coronary heart
disease. In this study, we compared resveratrol and analogues on their antioxidation and …

Effects of NO modulation on cardiac arrhythmias in the rat isolated heart

R Pabla, MJ Curtis - Circulation research, 1995 - Am Heart Assoc
It has been proposed that NO may function as an endogenous cardioprotectant. We have
investigated whether modulation of NO levels (detected in coronary effluent by …

Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart

T Ravingerová, J Matejíková, J Neckář… - Molecular and cellular …, 2007 - Springer
Endogenous cardiac protection against prolonged ischemic insult can be achieved by
repeated brief episodes of ischemia (hypoxia) or by cardiac adaptation to various stresses …

[HTML][HTML] ArrhythmoGenoPharmacoTherapy

A Tosaki - Frontiers in Pharmacology, 2020 - frontiersin.org
This review is focusing on the understanding of various factors and components governing
and controlling the occurrence of ventricular arrhythmias including (i) the role of various ion …

Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes

T Ravingerová, J Neckář, F Kolář - Biochemistry of Diabetes and …, 2003 - Springer
Different from clinical studies of diabetes mellitus (DM), experimental data reveal both,
higher and lower vulnerability of the heart to ischemic injury. We have previously …