Functionally altered myeloid cells play an important role in immune suppression in cancer,
in angiogenesis, and in tumor cells' invasion and metastases. Here, we report that inhibition …

Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring
a better characterization of the molecular determinants underlying disease progression and …

Herein we describe the synthesis and properties of substituted phenylaminopyrrolo [1, 2-a]
quinoxaline-carboxylic acid derivatives as a novel class of potent inhibitors of the human …

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on
bortezomib-regulated cellular pathways. In the present study, we investigated CK2 …

Despite the encouraging results of the innovative therapeutic treatments, complete
remission is uncommon in patients affected by chronic lymphocytic leukaemia, which …

CK2 is a constitutively active protein kinase that assuring a constant level of phosphorylation
to its numerous substrates supports many of the most important biological functions …

CK2 is a constitutively active Ser/Thr protein kinase which phosphorylates hundreds of
substrates. Since they are primarily related to survival and proliferation pathways, the best …

Constitutively active casein kinase 2 (CK2) signaling is a common feature of T-cell acute
lymphoblastic leukemia (T-ALL). CK2 phosphorylates PTEN (phosphatase and tensin …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …