Constitutively active casein kinase 2 (CK2) signaling is a common feature of T-cell acute
lymphoblastic leukemia (T-ALL). CK2 phosphorylates PTEN (phosphatase and tensin …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

CK2 and AKT display a high degree of cross-regulation of their respective functions, both
directly, through physical interaction and phosphorylation, and indirectly, through an intense …

Protein kinase CK2 sustains acute myeloid leukemia cell growth, but its role in leukemia
stem cells is largely unknown. Here, we discovered that the CK2 catalytic α and regulatory β …

The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved
serine/threonine kinase overexpressed in various human carcinomas and its high …

Simple Summary Acute myeloid leukemia (AML) is an aggressive blood cancer disease that
can only be cured by intensive anticancer treatment, and for several patients, allogeneic …

Background: Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a
promising therapeutic target in cancer. Recent studies have revealed an important role for …

Chronic lymphocytic leukemia (CLL) remains a therapeutic challenge. New immuno-
chemotherapeutic approaches have had a significant impact, improving overall survival …

Abstract Platelets, anucleated megakaryocyte (MK)-derived cells, play a major role in
hemostasis and arterial thrombosis. Although protein kinase casein kinase 2 (CK2) is readily …

The serine/threonine protein kinase CK2 is implicated in the regulation of fundamental
processes in eukaryotic cells. CK2 consists of two catalytic α or α'isoforms and two …