Since 1970, the isolated and identified components of Brucea javanica (L.) Merr. have been
known to contain anticancer effects, particularly antileukemic effect. In this study, the …

Cells exist in a dynamic state; they require the ability to rapidly adapt to their constantly
changing environment. Responses to these changes are mediated by signal transduction …

CK2 is a multifunctional, pleiotropic protein kinase involved in the regulation of cell
proliferation and survival. Since fibroblasts from Type 1 Diabetes patients (T1DM) with …

Casein kinase 2 (CK2) is an anti-apoptotic cancer-sustaining protein kinase. Its
crystallographic structures with the natural compounds coumestrol, a phytoestrogen, and …

In order to find the new potent CK2 inhibitors the 60 derivatives of 2-aminopyrimidinone and
their 6-aza-substituted analogs were synthesized and tested in vitro. Among them, the most …

Abstract Design of novel coumarin derivatives as CK2 inhibitors were attempted by targeting
the interaction with the hinge region. A set of substituents capable of forming a hydrogen …

恶性肿瘤严重威胁人类健康和生命, 影响社会经济的发展. 随着研究的深入,
恶性肿瘤发生发展机制, 生物学行为调控机理不断被揭示, 新的药物靶点陆续被发现 …

The complete eradication of Chronic Myeloid Leukemia is still challenging even in the era of
highly selective and potent BCR-ABL tyrosine kinase inhibitors (TKIs). The 'Achilles heel'of …

La leucemia mieloide aguda (LMA) es una neoplasia hematológica que se caracteriza por
la proliferación descontrolada de progenitores mieloides indiferenciados, y el desarrollo de …

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert
suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in …