The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Systemic inflammation as a therapeutic target in acute ischemic stroke

T Dziedzic - Expert review of neurotherapeutics, 2015 - Taylor & Francis
Acute systemic inflammatory reaction superimposed on chronic low-grade inflammation
accompanies acute ischemic stroke. Elevated blood levels of systemic inflammatory markers …

RNA-Seq identifies circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as potential biomarkers for acute ischemic stroke

S Tiedt, M Prestel, R Malik, N Schieferdecker… - Circulation …, 2017 - Am Heart Assoc
Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute
ischemic stroke (IS). MicroRNAs show promise as disease markers because of their cell type …

Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management

L Ramiro, A Simats… - Therapeutic …, 2018 - journals.sagepub.com
Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide.
Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to …

The role of CCL2/CCR2 axis in cerebral ischemia-reperfusion injury and treatment: from animal experiments to clinical trials

H Geng, L Chen, J Tang, Y Chen, L Wang - International journal of …, 2022 - mdpi.com
CC motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein
family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate …

Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis

A Bustamante, T Sobrino, D Giralt… - Journal of …, 2014 - Elsevier
We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor
outcome after stroke and its added predictive value over clinical information. Meta-analysis …

Chemokines in CNS injury and repair

A Jaerve, HW Müller - Cell and tissue research, 2012 - Springer
Recruitment of inflammatory cells is known to drive the secondary damage cascades that
are common to injuries of the central nervous system (CNS). Cell activation and infiltration to …

Acute neurofilament light chain plasma levels correlate with stroke severity and clinical outcome in ischemic stroke patients

HH Nielsen, CB Soares, SS Høgedal… - Frontiers in …, 2020 - frontiersin.org
Background: Ischemic stroke causes increased blood–brain barrier permeability and
release of markers of axonal damage and inflammation. To investigate diagnostic and …

Elevated concentrations of inflammation-related proteins in postnatal blood predict severe developmental delay at 2 years of age in extremely preterm infants

TM O'Shea, EN Allred, KCK Kuban, O Dammann… - The Journal of …, 2012 - Elsevier
OBJECTIVE: To evaluate the hypothesis that elevated levels of inflammation-related
proteins in early postnatal blood predict impaired mental and motor development in …

Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response

YI Luo, Y Zhou, W Xiao, Z Liang, J Dai, X Weng, X Wu - Brain research, 2015 - Elsevier
Ischemic stroke causes brain injury with activation of an inflammatory response that can
contribute to clinical impairment. As a novel cytokine of the interleukin-1 (IL-1) family, IL-33 …