Background: For more than a century, diagnostic pathologists have used morphologic
abnormalities of the nucleus as essential diagnostic features to distinguish benign from …

Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in
inflammatory and immune responses, as well as in regulation of expression of many other …

The number of patients surviving≥ 5 years after initial cancer diagnosis has significantly
increased during the last decades due to considerable improvements in the treatment of …

The discovery of actionable kinase gene rearrangements has revolutionized the therapeutic
landscape of thyroid carcinomas. Unsolved challenges include histopathologic recognition …

Thyroid cancer comprises different clinical and histological entities. Whereas differentiated
(DTCs) malignancies are sensitive to radioiodine therapy, anaplastic (ATCs) and medullary …

Thyroid carcinoma is the most common cancer in the endocrine system. Recent advances,
using next-generation sequencing, have shed light on the molecular pathogenesis of thyroid …

The incidence of thyroid cancer is rapidly increasing, mostly due to the overdiagnosis and
overtreatment of differentiated thyroid cancer (TC). The increasing use of potent preclinical …

Aims To characterise the mutational profiles of poorly differentiated thyroid carcinoma
(PDTC) and anaplastic thyroid carcinoma (ATC) and to identify markers with potential …

Next generation sequencing (NGS) allows parallel sequencing of multiple genes at a very
high depth of coverage. The need to analyze a variety of targets for diagnostic/prognostic …

Background A growing body of evidences shows that systemic inflammatory responses are
involved in patient prognosis in multiple cancers. Combinations of peripheral leukocyte …