Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia

MR de Lima Conceição, JL Teixeira-Fonseca… - Pharmacological …, 2024 - Springer
Background Amiodarone (AMIO) is an antiarrhythmic drug with the pKa in the physiological
range. Here, we explored how mild extracellular pH (pHe) changes shape the interaction of …