Inducing a long-lasting as well as broad and potent immune response by generating broadly
neutralizing antibodies is a major goal and at the same time the main challenge of …

BLyS family members govern selection and survival of cells in the pre-immune B cell
compartment, and emerging evidence suggests similar roles in antigen-experienced B cell …

Systemic lupus erythematosus (SLE) is a complex immune disorder in which loss of
tolerance to nucleic acid antigens and other cross‐reactive antigens is associated with the …

B lymphocyte–intrinsic Toll-like receptor (TLR) signals amplify humoral immunity and can
exacerbate autoimmune diseases. We identify a new mechanism by which TLR signals may …

Retinoic acid (RA) increases antibody production in vivo but its role in B-cell activation is
unclear. In a model of purified mouse splenic B cells stimulated by CD40 coreceptor (as a …

CD1d-restricted natural killer (NKT) cells are important contributors to antigen-specific
antibody responses. There is, therefore, considerable interest in the design and …

Introduction: The lymphadenoid tissues in the upper airway are sparse and organized
lympho-epithelial structures playing an important role against foreign pathogens, with the …

Results Double positive staining of CD5+ CD1d+ Bregs represents (19.27±1.52) from
PBMCs,(33.32±2.95) from B cells accordingly (n= 40). Through ELISA assays, it has been …

Development of germinal center (GC) B cells and follicular helper T (Tfh) cells requires the
transcription factor B‐cell lymphoma 6 (Bcl6). Expression of Bcl6 in B cells and helper T cells …

In this study, we investigated the mouse dendritic cell (DC) receptor, complement receptor 4
(CR4; CD11c/CD18), as an immunotarget for triggering humoral immunity. Comparison of …