Der induzierbare Kostimulator ICOS ist ein zu CD28 strukturell und funktionell verwandtes
Molekül, das eine wichtige regulatorische Rolle bei der T-Zelleffektorfunktion spielt. Eine …

Lymphocytes, which are white blood cells, comprise a fundamentally important compartment
of the immune system since they are key players in controlling how specific and effective an …

Transplantation, historically attributed to be T cell driven, is experiencing a revision
regarding the criticality of B cells. This reconsideration has evolved in part from the …

Long-lived plasma cells constitutively produce protective antibody titers and persist in
survival niches in the bone marrow and spleen. Identification of the cellular …

Background The X-linked hyper-IgM syndrome type I (HIGM1) is caused by inactivating
mutations in the CD40 ligand gene (CD40LG) that disrupt the T cell helper function on B …

Streptococcus pyogenes, also known as Group A Streptococcus (GAS) has been associated
with a range of diseases from the mild pharyngitis and pyoderma to more severe invasive …

Germinal centres (GCs) are the sites where V-gene hypermutation and B cell selection are
taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen …

Auch im Hinblick auf eine ansteigende Weltbevölkerung und damit verbundenem erhöhten
Nahrungsmittelbedarf gewinnt das Huhn zunehmend an Bedeutung als …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world.
It is characterized by the monoclonal expansion of small mature-looking B cells that …

Transcriptional regulation of CD8+ T cell differentiation during acute and chronic viral
infections is an intricate web made up of many of transcription factors. While several …