Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Millions of patients are suffering from ischemic stroke, it is urgent to figure out the
pathogenesis of cerebral ischemia–reperfusion (I/R) injury in order to find an effective cure …

Irisin protects the cardiovascular system against vascular diseases. However, its role in
chronic kidney disease (CKD)-associated vascular calcification (VC) and the underlying …

Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and
apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice …

The global COVID-19 epidemic has spread rapidly around the world and caused the death
of more than 5 million people. It is urgent to develop effective strategies to treat COVID-19 …

Pyroptosis is a programmed cell death mode discovered in recent years. It is caused by
inflammasomes and the perforation of Gasdermin family proteins, and results in the release …

Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory
response and is the most common cardiovascular disease (CVD). Iron is an essential …

Increasing evidences demonstrate that chlorogenic acid (CGA), a polyphenol with multiple
effects such as anti-inflammatory and anti-oxidation, protects against myocardial ischemia …

Pyroptosis is a kind of programmed cell death closely related to inflammation. The pathways
that mediate pyroptosis can be divided into the Caspase-1-dependent canonical pathway …

Doxorubicin (DOX) is a highly effective and extensively used chemotherapeutic drug but is
limited by its cardiotoxicity. In our previous study, we showed that DOX-induced …