Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review

K Devaraja, S Aggarwal, M Singh - Vaccines, 2023 - mdpi.com
Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second
only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical …

Clinico-pathological peculiarities of human papilloma virus driven head and neck squamous cell carcinoma: A comprehensive update

K Devaraja, S Aggarwal, SS Verma, SC Gupta - Life Sciences, 2020 - Elsevier
Aims The current article provides a detailed account of the current understanding of
molecular and clinico-pathological aspects of Human papilloma virus (HPV) driven head …

Glioblastoma therapy: rationale for a mesenchymal stem cell-based vehicle to carry recombinant viruses

S Ali, Q Xia, T Muhammad, L Liu, X Meng… - Stem Cell Reviews and …, 2021 - Springer
Evasion of growth suppression is among the prominent hallmarks of cancer. Phosphatase
and tensin homolog (PTEN) and p53 tumor-suppressive pathways are compromised in most …

Engineering a single-chain variable fragment of cetuximab for CAR T-cell therapy against head and neck squamous cell carcinomas

C Haist, Z Poschinski, A Bister, MJ Hoffmann… - Oral Oncology, 2022 - Elsevier
The monoclonal antibody cetuximab recognizes domain III of the epithelial growth factor
receptor (EGFR) with high-affinity and is an important element in the treatment of several …

Suppression of head and neck cancer cell survival and cisplatin resistance by GRP78 small molecule inhibitor YUM70

V Yamamoto, B Wang, AS Lee - Frontiers in Oncology, 2023 - frontiersin.org
Background Head and neck squamous cell carcinoma (HNSCC) is one of the leading
causes of cancer-related death worldwide. Surgical resection, radiation and chemotherapy …

Remodeling the tumor myeloid landscape to enhance antitumor antibody immunotherapies

K Hussain, MS Cragg, SA Beers - Cancers, 2021 - mdpi.com
Simple Summary In addition to cancer cells themselves, tumors consist of several cell types
that either function to suppress or promote tumor growth and disease progression …

p53, a victim of the prion fashion

O Billant, G Friocourt, P Roux, C Voisset - Cancers, 2021 - mdpi.com
Simple Summary The tumor suppressor gene TP53 is found mutated in around half of
human cancers. The accumulation of the mutant p53 protein in the form of aggregates in …

Current status of systemic therapy in head and neck cancer

A Mittal, A Sharma - Journal of Chemotherapy, 2022 - Taylor & Francis
There are several controversies in the management of head and neck cancer (SCCHN).
Although combined modality treatment is standard in locally advanced SCCHN (LA …

Current insights and advancements in head and neck Cancer: emerging biomarkers and therapeutics with cues from single cell and 3D model omics profiling

Y Jawa, P Yadav, S Gupta, SV Mathan… - Frontiers in …, 2021 - frontiersin.org
Head and neck cancer (HNC) is among the ten leading malignancies worldwide, with India
solely contributing one-third of global oral cancer cases. The current focus of all cutting-edge …

Distant metastasis at the time of presentation of head and neck squamous cell carcinoma: a retrospective chart review from a tertiary cancer care centre

CS Majitha, DR Nayak, S Shetty, K Devaraja… - The Journal of …, 2024 - cambridge.org
ObjectiveTo evaluate the rates and patterns of distant metastasis in head and neck SCC at
the time of presentation and to study the association between distant metastasis with pre …