Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

P Wang, H Yang, C Liu, M Qiu, X Ma, Z Mao… - Chinese Chemical …, 2021 - Elsevier
Caspases are a family of proteases that play critical roles in controlling inflammation and cell
death. Apoptosis is a caspase-3 mainly controlled behavior to avoid inflammation and …

Biosensors for Caspase-3: From chemical methodologies to biomedical applications

Q Lei, X Huang, L Zheng, F Zheng, J Dong, F Chen… - Talanta, 2022 - Elsevier
Caspase-3 plays irreplaceable roles in apoptosis and related diseases. An imbalance in the
measured levels of Caspase-3 is implicated in irreversible apoptosis. Therefore, the …

The mechanisms and potential of stem cell therapy for penile fibrosis

U Milenkovic, M Albersen, F Castiglione - Nature Reviews Urology, 2019 - nature.com
Fibrosis is often caused by chronic tissue injury leading to a persisting inflammatory
response with excessive accumulation of extracellular connective tissue proteins. Peyronie's …

Molecular pathogenesis and treatment of cavernous nerve injury-induced erectile dysfunction: a narrative review

G Song, P Hu, J Song, J Liu, Y Ruan - Frontiers in Physiology, 2022 - frontiersin.org
Introduction: Erectile dysfunction (ED) is a common complication after radical prostatectomy
(RP), and it seriously affects the quality of life in patients and their partners. The primary …

The protective effect of microRNA-21 in neurons after spinal cord injury

T Zhang, S Ni, Z Luo, Y Lang, J Hu, H Lu - Spinal cord, 2019 - nature.com
Study design Experimental animal study. Objectives To validate the anti-apoptosis effect of
microRNA-21 in neurons after spinal cord injury (SCI) and explore the mechanism. Setting …

Sexual recovery following prostate cancer: recommendations from 2 established Canadian sexual rehabilitation clinics

S Elliott, A Matthew - Sexual medicine reviews, 2018 - Elsevier
Introduction Supportive sexual health care is much-needed adjuvant care to oncologic
management for men with prostate cancer (PCa). Aim To inspire the initiation of …

M1 macrophages are predominantly recruited to the major pelvic ganglion of the rat following cavernous nerve injury

H Matsui, NA Sopko, JL Hannan… - The journal of sexual …, 2017 - academic.oup.com
Introduction Neurogenic erectile dysfunction is a common sequela of radical prostatectomy.
The etiology involves injury to the autonomic cavernous nerves, which arise from the major …

Bilateral cavernous nerve crush injury in the rat model: a comparative review of pharmacologic interventions

NM Haney, HMT Nguyen, M Honda… - Sexual Medicine …, 2018 - academic.oup.com
Introduction It is common for men to develop erectile dysfunction after radical prostatectomy.
The anatomy of the rat allows the cavernous nerve (CN) to be identified, dissected, and …

Low-intensity electrostimulation enhances neuroregeneration and improves erectile function in a rat model of cavernous nerve injury

M Sturny, S Karakus, R Fraga-Silva… - The journal of sexual …, 2022 - academic.oup.com
Background Neurogenic erectile dysfunction (ED) following radical prostatectomy (RP) is a
frequent complication often leading to erectile tissue remodeling and permanent ED. Low …

Cavernous nerve injury by radiation therapy may potentiate erectile dysfunction in rats

J Mahmood, CQ Connors, AA Alexander… - International Journal of …, 2017 - Elsevier
Purpose/Objectives Radiation-induced erectile-dysfunction (RiED) is one of the most
common side effects of radiation therapy (RT) and significantly reduces the quality of life …