[HTML][HTML] Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure

D Xueyang, M Zhanqiang, M Chunhua, H Kun - Oncotarget, 2016 - ncbi.nlm.nih.gov
Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments
induced by smoke exposure - PMC Back to Top Skip to main content NIH NLM Logo Access …

siRNA mediated downregulation of RhoA expression reduces oxidative induced apoptosis in retinal ganglion cells

Q Liu, C Liu, B Lei - Current Molecular Medicine, 2024 - ingentaconnect.com
Backgrounds: Glaucoma is the second leading cause of blindness. Apoptosis of retinal
ganglion cells (RGCs) is an important mechanism of glaucomatous optic injury. Rho kinase …

Electroacupuncture Pretreatment Regulates Apoptosis of Myocardial Ischemia‐Reperfusion Injury in Rats Through RhoA/p38MAPK Pathway Mediated by miR‐133a …

Y Han, S Chen, H Wang, X Peng - … ‐Based Complementary and …, 2021 - Wiley Online Library
The electroacupuncture (EA) pretreatment possesses a beneficial effect on myocardial
ischemia/reperfusion (I/R) injury. However, the molecular mechanism of the EA effect is not …

[HTML][HTML] Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration

L Baker, M Tar, AH Kramer, GA Villegas… - Jci Insight, 2021 - ncbi.nlm.nih.gov
The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here,
we identify the MT-severing enzyme fidgetin-like 2 (FL2) as a negative regulator of axon …

Phosphodiesterase type 5 in men with vasculogenic and post‐radical prostatectomy erectile dysfunction: is there a molecular difference?

S Karakus, B Musicki, AL Burnett - BJU international, 2018 - Wiley Online Library
Objectives To clarify the molecular basis of penile erection at the human level and
distinguish the mechanisms underlying vasculogenic and post‐radical prostatectomy (RP) …

Intracavernosal pressure recording to evaluate erectile function in rodents

F Pan, J Zhang, Y Liu, L Lu, X Qiu, K Lv… - JoVE (Journal of …, 2018 - jove.com
Erectile dysfunction (ED) is defined as the inability to attain or keep an erection of the penis,
and this has become a prevalent male sexual disorder. Rodents are employed by many …

Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia

JL Hannan, SA Powers, VM Wang… - International …, 2017 - Springer
Introduction and hypothesis Bilateral pelvic nerve injury (BPNI) is a model of post-radical
hysterectomy neuropraxia, a common sequela. This study assessed the time course of …

The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin

Y Zheng, Q Ouyang, R Fu, L Liu, H Zhang, X Hu… - Cell Death & …, 2018 - nature.com
The effects of MC-3129, a synthetic cyclohexene derivative, on cell viability and apoptosis
have been investigated in human leukemia cells. Exposure of leukemia cells to MC-3129 …

Effect of HongJing I in treating erectile function and regulating RhoA pathway in a rat model of bilateral cavernous nerve injury

M Ye, F Zhao, K Ma, K Zhou, WJ Huang… - Evidence‐Based …, 2019 - Wiley Online Library
HongJing I (HJI), a traditional Chinese herbal formula, has been confirmed to be effective for
the clinical treatment of erectile dysfunction (ED). However, the mechanism of action of HJI …

Protective effect of extract of Bletilla striata on isoflurane induced neuronal injury by altering PI3K/Akt pathway

G Zhao, K Li, J Chen, L Li - Translational Neuroscience, 2018 - degruyter.com
Background Present investigation evaluates the neuroprotective effect of Bletilla striata on
isoflurane induced neuronal injury rat model. Methodology Neuronal injury was induced by …