S-nitrosylation of NOS pathway mediators in the penis contributes to cavernous nerve injury-induced erectile dysfunction

B Musicki, AK Bhunia, S Karakus… - International journal of …, 2018 - nature.com
Abstract cGMP-independent nitric oxide (NO) signaling occurs via S-nitrosylation. We
evaluated whether aberrant S-nitrosylation operates in the penis under conditions of …

Upregulated SHP‐2 expression in the epileptogenic zone of temporal lobe epilepsy and various effects of SHP099 treatment on a pilocarpine model

J Yue, C Liang, K Wu, Z Hou, L Wang, C Zhang… - Brain …, 2020 - Wiley Online Library
Temporal lobe epilepsy (TLE) is defined as the sporadic occurrence of spontaneous
recurrent seizures, and its pathogenesis is complex. SHP‐2 (Src homology 2‐containing …

[HTML][HTML] The effect of cavernous nerve traction on erectile function in rats

H Li, L Chen, T Wang, S Wang, J Liu - PLoS One, 2017 - journals.plos.org
We performed this study to evaluate the effect of cavernous nerve (CN) traction on erectile
function in rats. Thirty-two 8-week-old Sprague–Dawley rats were divided into four groups …

[HTML][HTML] Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush

W Huang, Q Lan, L Jiang, W Yan, F Tang… - Molecular Biology …, 2020 - Springer
To investigate the functional role of fasudil in optic nerve crush (ONC), and further explore its
possible molecular mechanism. After ONC injury, the rats were injected intraperitoneally …

cAMP‐dependent post‐translational modification of neuronal nitric oxide synthase neuroprotects penile erection in rats

S Karakus, B Musicki, JD La Favor… - BJU international, 2017 - Wiley Online Library
Objectives To evaluate neuronal nitric oxide (NO) synthase (nNOS) phosphorylation, nNOS
uncoupling, and oxidative stress in the penis and major pelvic ganglia (MPG), before and …

Galanin administration partially restores erectile function after cavernous nerve injury and mediates endogenous nitrergic nerve outgrowth in vitro

E Weyne, JL Hannan, T Gevaert… - The Journal of …, 2018 - academic.oup.com
Background Previously, we found that the neuropeptide galanin was strongly upregulated
soon after bilateral cavernous nerve injury (BCNI) and that galanin and its receptors were …

[HTML][HTML] RhoA/ROCK activation in major pelvic ganglion mediates caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury

M Bell, NA Sopko, H Matsui, JL Hannan… - Neural regeneration …, 2017 - journals.lww.com
Severe erectile dysfunction (ED) remains a significant side effect among men following
surgical intervention for treatment of clinically localized prostate cancer, despite …

Genome Editing to Abrogate Muscle Atrophy

T Yang, P Gokulnath, X Meng, G Li, J Xiao - Genome Editing in …, 2022 - Springer
Muscle atrophy is a multifactor syndrome, which not only decreases the patients' quality of
life significantly but also increases the morbidity and mortality of patients with chronic …

RhoA/ROCK 在主要盆腔神经节中的活化介导海绵状神经损伤后半胱氨酸蛋白酶-3 依赖性硝化神经元凋亡

M Bell, NA Sopko, H Matsui, JL Hannan… - 中国神经再生研究 …, 2017 - sjzsyj.com.cn
尽管如今神经保护技术已经取得了很大进步, 但严重勃起功能障碍(ED) 在前列腺癌外科手术
治疗之后仍然具有临床局限性和显著副作用. 由前列腺切除术引起的轴突损伤类型是典型的周围 …

[图书][B] Fidgetin-Like 2: a Novel Negative Regulator of Axonal Growth and a Promising Therapeutic Target for Promoting Nerve Regeneration

LA Baker - 2020 - search.proquest.com
The microtubule (MT) cytoskeleton is a key regulator of axonal growth and guidance. Here,
we characterize the role of the MT severing enzyme fidgetin-like 2 (FL2) in regulating axonal …