The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis
Leishmaniasis is a parasitic disease and categorised as a neglected tropical disease (NTD).
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …
Synthetic product-based approach toward potential antileishmanial drug development
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …
(NTD) with no effective vaccines available. The available chemotherapeutics against …
Exploring the paradox of defense between host and Leishmania parasite
Leishmaniasis, a neglected tropical disease, still remains a global concern for the
healthcare sector. The primary causative agents of the disease comprise diverse …
healthcare sector. The primary causative agents of the disease comprise diverse …
Ivermectin presents effective and selective antileishmanial activity in vitro and in vivo against Leishmania infantum and is therapeutic against visceral leishmaniasis
TAR Reis, JA Oliveira-da-Silva, GSV Tavares… - Experimental …, 2021 - Elsevier
Abstract Treatment for visceral leishmaniasis (VL) is hindered mainly by the toxicity and/or
high cost of therapeutic drugs. In addition, parasite resistance has been registered. Thus …
high cost of therapeutic drugs. In addition, parasite resistance has been registered. Thus …
Antileishmanial activity of 3, 4, 5-trisubstituted isoxazoles by interaction with Leishmania amazonensis plasma membrane
The isoxazole core has been identified as an essential privileged structure in discovering
new and potent leishmanicidal agents. Thus, the present study reports the in vitro activity of …
new and potent leishmanicidal agents. Thus, the present study reports the in vitro activity of …
Discovery of New Chemical Tools against Leishmania amazonensis via the MMV Pathogen Box
The protozoan parasite Leishmania causes a spectrum of diseases and there are over 1
million infections each year. Current treatments are toxic, expensive, and difficult to …
million infections each year. Current treatments are toxic, expensive, and difficult to …
Proteomic alterations in Paracoccidioides brasiliensis caused by exposure to curcumin
OB Rocha, KSF e Silva, MAB de Carvalho Junior… - Journal of …, 2022 - Elsevier
Paracoccidioides spp. are the etiological agent of paracoccidioidomycosis, a disease that
causes skin lesions and affect the lungs and other organs. The current management of the …
causes skin lesions and affect the lungs and other organs. The current management of the …
Antileishmanial activities of three chalcone derivatives and their association with plasma membrane rigidity as assessed by EPR spectroscopy
EN Borges, L Alonso, MB Silveira, RB Balbinot… - Journal of Molecular …, 2023 - Elsevier
Novel chalcone-like compounds, LQFM332 (4), LQFM333 (5), and LQFM341 (6), were
synthesized and their activity against Leishmania (L.) amazonensis was evaluated and …
synthesized and their activity against Leishmania (L.) amazonensis was evaluated and …
[HTML][HTML] Cell Death in Leishmania donovani promastigotes in response to Mammalian Aurora Kinase B Inhibitor–Hesperadin
Deciphering how hesperadin, a repurposed mammalian aurora kinase B inhibitor, affects
the cellular pathways in Leishmania donovani might be beneficial. This investigation sought …
the cellular pathways in Leishmania donovani might be beneficial. This investigation sought …
Analysis of the Interactions of Amphotericin B with the Leishmania Plasma Membrane Using EPR Spectroscopy
L Alonso, SA Mendanha, ML Dorta… - The Journal of Physical …, 2020 - ACS Publications
Electron paramagnetic resonance (EPR) spectroscopy of spin labels was used to study the
interactions of amphotericin B (AmB) with the plasma membrane of Leishmania …
interactions of amphotericin B (AmB) with the plasma membrane of Leishmania …