Advances in targeting the WNT/β-catenin signaling pathway in cancer
WNT/β-catenin signaling orchestrates various physiological processes, including embryonic
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …
Bioinformatics approaches for anti-cancer drug discovery
Drug discovery is important in cancer therapy and precision medicines. Traditional
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …
Engineering in medicine to address the challenge of cancer drug resistance: from micro-and nanotechnologies to computational and mathematical modeling
Drug resistance has profoundly limited the success of cancer treatment, driving relapse,
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies …
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies …
[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications
Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …
improving continuously, the complexity and heterogeneity of this group of diseases …
Benchmarking the performance of irregular computations in AutoDock-GPU molecular docking
Irregular applications can be found in different scientific fields. In computer-aided drug
design, molecular docking simulations play an important role in finding promising drug …
design, molecular docking simulations play an important role in finding promising drug …
Systems biology approaches to a rational drug discovery paradigm
P Prathipati, K Mizuguchi - Current topics in medicinal chemistry, 2016 - ingentaconnect.com
Ligand-and structure-based drug design approaches complement phenotypic and target
screens, respectively, and are the two major frameworks for guiding early-stage drug …
screens, respectively, and are the two major frameworks for guiding early-stage drug …
[HTML][HTML] Proteomic profiling of BRAFV600E mutant colon cancer cells reveals the involvement of nucleophosmin/c-Myc axis in modulating the response and resistance …
BRAFV600E mutations are found in approximately 10% of colorectal cancer patients and
are associated with worse prognosis and poor outcomes with systemic therapies. The aim of …
are associated with worse prognosis and poor outcomes with systemic therapies. The aim of …
[HTML][HTML] Mathematical Modeling for the Assessment of Public Policies in the Cancer Health-Care System Implemented for the Colombian Case
D Rojas-Díaz, ME Puerta-Yepes… - International Journal of …, 2023 - mdpi.com
The incidence of cancer has been constantly growing worldwide, placing pressure on health
systems and increasing the costs associated with the treatment of cancer. In particular, low …
systems and increasing the costs associated with the treatment of cancer. In particular, low …
[HTML][HTML] A comprehensive tool for tumor precision medicine with pharmaco-omics data analysis
Background: Cancer precision medicine is an effective strategy to fight cancers by bridging
genomics and drug discovery to provide specific treatment for patients with different genetic …
genomics and drug discovery to provide specific treatment for patients with different genetic …
Predicting novel therapies and targets: regulation of Notch3 by the bromodomain protein BRD4
Systematic approaches for accurate repurposing of targeted therapies are needed. We
developed and aimed to biologically validate our therapy predicting tool (TPT) for the …
developed and aimed to biologically validate our therapy predicting tool (TPT) for the …