Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis

MR Aburto, JF Cryan - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

[HTML][HTML] Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy

X Kang, HCH Lau, J Yu - Cell Reports Medicine, 2024 - cell.com
Immunotherapy has emerged as a robust approach against cancer, yet its efficacy has
varied among individuals, accompanied by the occurrence of immune-related adverse …

Hundreds of antimicrobial peptides create a selective barrier for insect gut symbionts

J Lachat, G Lextrait, R Jouan… - Proceedings of the …, 2024 - National Acad Sciences
The spatial organization of gut microbiota is crucial for the functioning of the gut ecosystem,
although the mechanisms that organize gut bacterial communities in microhabitats are only …

[HTML][HTML] Gut microbiota contributes to bisphenol A-induced maternal intestinal and placental apoptosis, oxidative stress, and fetal growth restriction in pregnant ewe …

H Zhang, X Zha, B Zhang, Y Zheng, M Elsabagh… - Microbiome, 2024 - Springer
Abstract Background Bisphenol A (BPA) is an environmental contaminant with endocrine-
disrupting properties that induce fetal growth restriction (FGR). Previous studies on pregnant …

[HTML][HTML] The gut microbiota and diabetes: research, translation, and clinical applications – 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum

M Byndloss, S Devkota, F Duca, JH Niess… - Diabetologia, 2024 - Springer
This article summarises the state of the science on the role of the gut microbiota (GM) in
diabetes from a recent international expert forum organised by Diabetes, Diabetes Care …

Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria

Y Chen, S Lin, L Wang, Y Zhang, H Chen… - Nature Biomedical …, 2024 - nature.com
The breakdown of the gut's mucosal barrier that prevents the infiltration of microorganisms,
inflammatory cytokines and toxins into bodily tissues can lead to inflammatory bowel …

Mechanics limits ecological diversity and promotes heterogeneity in confined bacterial communities

T Ma, J Rothschild, F Halabeya… - Proceedings of the …, 2024 - National Acad Sciences
Multispecies bacterial populations often inhabit confined and densely packed environments
where spatial competition determines the ecological diversity of the community. However …

[HTML][HTML] Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study

C Liu, X Liu, X Li - Frontiers in Microbiology, 2024 - frontiersin.org
Background Accumulating evidence suggests that alterations in gut microbiota composition
are associated with the hidradenitis suppurativa (HS). However, the causal association …

[HTML][HTML] Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

J Xiao, X Guo, Z Wang - Frontiers in Immunology, 2024 - frontiersin.org
The human intestinal tract constitutes a complex ecosystem, made up of countless gut
microbiota, metabolites, and immune cells, with hypoxia being a fundamental environmental …

Spatial features of skip lesions in Crohn's disease

R Herren, N Geva-Zatorsky - Trends in Immunology, 2024 - cell.com
Skip lesions are an enigmatic spatial feature characterizing Crohn's disease (CD). They
comprise inflamed and adjacent non-inflamed tissue sections with a clear demarcation …