The prone posture is known to have numerous effects on gas exchange, both under normal
conditions and in patients with ARDS. Clinical studies have consistently demonstrated …

The structure of the lung, with its delicate network of airspaces and capillaries, means that
gravity has a profound influence on its function. Studies of lung function in the absence of …

Recent evidence suggests that endothelial dysfunction and pathology of pulmonary vascular
responses may serve as a precursor to smoking-associated emphysema. Although it is …

Specific ventilation (SV) is the ratio of fresh gas entering a lung region divided by its end-
expiratory volume. To quantify the vertical (gravitationally dependent) gradient of SV in eight …

From the first measurements of the distribution of pulmonary blood flow using radioactive
tracers by West and colleagues (J Clin Invest 40: 1–12, 1961) allowing gravitational …

Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Gravity has played a critical role in the development of terrestrial life. A key event in
evolution has been the development of mechanisms to sense and transduce gravitational …

Assessment of lung effective transverse relaxation time (T2*) may play an important role in
the detection of structural and functional changes caused by lung diseases such as …

Background Clustering key clinical characteristics of participants in the Severe Asthma
Research Program (SARP), a large, multicenter prospective observational study of patients …

Multiple-breath washout hyperpolarized 3He MRI was used to calculate regional parametric
images of fractional ventilation (r) as the ratio of fresh gas entering a volume unit to the total …