Rationale: Regional hypoventilation in bronchoconstricted patients with asthma is spatially
associated with reduced perfusion, which is proposed to result from hypoxic pulmonary …

Purpose To demonstrate the feasibility of a multi‐breath xenon‐polarization transfer contrast
(XTC) MR imaging approach for simultaneously evaluating regional ventilation and gas …

The function of the pulmonary circulation is truly multi-scale, with blood transported through
vessels from centimeter to micron scale. There are scale-dependent mechanisms that …

We used quantitative Single Photon Emission Computed Tomography (SPECT) to study the
effect of the upright posture on regional lung blood flow and ventilation. Nine (upright) plus …

Background Prone positioning has been used as an intervention to improve oxygenation in
critically ill patients with acute respiratory distress syndrome. During the COVID-19 …

Biophysically-based computational models provide a tool for integrating and explaining
experimental data, observations, and hypotheses. Computational models of the pulmonary …

Liquefaction is one of the most intriguing aspects of human tuberculosis. It is a major cause
of the transition from the infection to active disease (tuberculosis, TB) as well as the …

The primary function of the pulmonary circulation is to deliver blood to the alveolar
capillaries to exchange gases. Distributing blood over a vast surface area facilitates gas …

Pulmonary embolism (PE) is the most common cause of acute pulmonary hypertension, yet
it is commonly undiagnosed, with risk of death if not recognized promptly and managed …

Mathematical models have been central to understanding the interaction between neural
control and breathing. Models of the entire respiratory system—which comprises the lungs …