A guide for the diagnosis of rare and undiagnosed disease: beyond the exome
Rare diseases affect 30 million people in the USA and more than 300–400 million
worldwide, often causing chronic illness, disability, and premature death. Traditional …
worldwide, often causing chronic illness, disability, and premature death. Traditional …
Engineered materials for organoid systems
Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear
how convergent biological processes in affected individuals may give rise to symptoms …
how convergent biological processes in affected individuals may give rise to symptoms …
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
The rise of three-dimensional human brain cultures
SP Pașca - Nature, 2018 - nature.com
Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …
Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Recent developments in stem cell biology have enabled the study of cell fate decisions in
early human development that are impossible to study in vivo. However, understanding how …
early human development that are impossible to study in vivo. However, understanding how …
Common genetic variation drives molecular heterogeneity in human iPSCs
Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous
potential to provide improved cellular models of human disease. However, variable genetic …
potential to provide improved cellular models of human disease. However, variable genetic …
Intratumoral heterogeneity: more than just mutations
K Hinohara, K Polyak - Trends in cell biology, 2019 - cell.com
Most human tumors are composed of genetically and phenotypically heterogeneous cancer
cell populations, which poses a major challenge for the clinical management of cancer …
cell populations, which poses a major challenge for the clinical management of cancer …
Induced pluripotent stem cells 10 years later: for cardiac applications
Y Yoshida, S Yamanaka - Circulation research, 2017 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …