Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

S Kabu, Y Gao, BK Kwon, V Labhasetwar - Journal of Controlled Release, 2015 - Elsevier
Spinal cord injury (SCI) results in devastating neurological and pathological consequences,
causing major dysfunction to the motor, sensory, and autonomic systems. The primary …

The emerging role of long non‐coding RNA in spinal cord injury

Z Shi, B Pan, S Feng - Journal of Cellular and Molecular …, 2018 - Wiley Online Library
Spinal cord injury (SCI) is a significant health burden worldwide which causes permanent
neurological deficits, and there are approximately 17,000 new cases each year. However …

A Localized Materials‐Based Strategy to Non‐Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model

AS Khalil, D Hellenbrand, K Reichl… - Advanced …, 2022 - Wiley Online Library
Spinal cord injury often results in devastating consequences for those afflicted, with very few
therapeutic options. A central element of spinal cord injuries is astrogliosis, which forms a …

Immunobiology of spinal cord injuries and potential therapeutic approaches

A Ahmed, AA Patil, DK Agrawal - Molecular and cellular biochemistry, 2018 - Springer
The incidence of spinal cord injuries (SCI) is high every year. As the spinal cord is the
highway that allows for the brain to control the rest of the body, spinal cord injuries greatly …

Research progress on the regulatory role of microRNAs in spinal cord injury

XD Guo, XG He, FG Yang, MQ Liu, YD Wang… - Regenerative …, 2021 - Taylor & Francis
Spinal cord injury (SCI) is a severe CNS injury that results in abnormalities in, or loss of,
motor, sensory and autonomic nervous function. miRNAs belong to a new class of …

Triptolide improves spinal cord injury by promoting autophagy and inhibiting apoptosis

N Zhu, J Ruan, X Yang, Y Huang, Y Jiang… - Cell Biology …, 2020 - Wiley Online Library
We investigated the effect of triptolide (TP) on spinal cord injury (SCI), and its underlying
mechanism. Following the establishment of the SCI model using YFP H‐line transgenic …

Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review

SD Alizadeh, MR Jalalifar, Z Ghodsi, M Sadeghi-Naini… - Spinal Cord, 2024 - nature.com
Abstract Study design A Systematic Review Objectives To determine the therapeutic efficacy
of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of spinal …

Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation

Z Li, Z Li, Z Chen, H Sun, Z Yuan, X Wang… - Frontiers in …, 2022 - frontiersin.org
Background: Spinal cord injury (SCI) is a common disorder of the central nervous system
with considerable socio-economic burden. Andrographolide (Andro), the main active …

MiR-615 regulates NSC differentiation in vitro and contributes to spinal cord injury repair by targeting LINGO-1

H Wu, L Ding, Y Wang, TB Zou, T Wang, W Fu… - Molecular …, 2020 - Springer
LINGO-1 (LRR and Ig domain–containing NOGO receptor interacting protein 1) is a viable
target for spinal cord injury (SCI) repair due to its potent negative regulation in neuron …

High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke

J Luo, Y Feng, Z Hong, M Yin, H Zheng… - Neural Regeneration …, 2024 - journals.lww.com
Proliferation of neural stem cells is crucial for promoting neuronal regeneration and
repairing cerebral infarction damage. Transcranial magnetic stimulation (TMS) has recently …